BDBM320708 (S)-or (R)-1-(1-(4-(Difluoromethyl)- 3-fluorophenyl)-2-methylpropyl)-6- (dimethylamino)-3-(hydroxymethyl)- 1H-pyrazolo[3,4-d]pyrimidin-4(5H)- one::US10174037, Example 114::US10174037, Example 115

SMILES CC(C)C(c1ccc(C(F)F)c(F)c1)n1nc(CO)c2c1nc([nH]c2=O)N(C)C

InChI Key InChIKey=IWGRCNUXWVOUFX-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 320708   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320708(US10174037, Example 115 | (S)-or (R)-1-(1-(4-(Difl...)
Affinity DataKi:  0.210nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320708(US10174037, Example 115 | (S)-or (R)-1-(1-(4-(Difl...)
Affinity DataKi:  0.320nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320708(US10174037, Example 115 | (S)-or (R)-1-(1-(4-(Difl...)
Affinity DataKi:  0.710nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320708(US10174037, Example 115 | (S)-or (R)-1-(1-(4-(Difl...)
Affinity DataKi:  0.790nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent