BDBM320789 (R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)ethyl)-6- (dimethylamino)-3-(fluoromethyl)-1H- pyrazolo[3,4-d]pyrimidin-4(5H)-one::US10174037, Example 194::US10174037, Example 195::US10174037, Example 210::US10174037, Example 211

SMILES CC(c1ccc(cc1)C(C)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C

InChI Key

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 320789   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320789((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)eth...)
Affinity DataKi:  0.0480nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320789((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)eth...)
Affinity DataKi:  0.0700nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320789((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)eth...)
Affinity DataKi:  0.140nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320789((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)eth...)
Affinity DataKi:  0.170nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320789((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)eth...)
Affinity DataKi:  3.30nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320789((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)eth...)
Affinity DataKi:  6.10nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320789((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)eth...)
Affinity DataKi:  235nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent