BDBM320837 (R)- or (S)-1- (Cyclopropyl(4- (trifluoromethoxy) phenyl)methyl)-6-hydroxy- 3-(2,2,2-trifluoroelhyl)- 1H-pyrazolo[3,4- d]pyrimidin-4(5H)-one::US10174037, Example 242::US10174037, Example 243

SMILES Oc1nc2n(nc(CC(F)(F)F)c2c(=O)[nH]1)C(C1CC1)c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=ZQDFIRJDWJQPNL-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 320837   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320837((R)- or (S)-1- (Cyclopropyl(4- (trifluoromethoxy) ...)
Affinity DataKi:  150nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320837((R)- or (S)-1- (Cyclopropyl(4- (trifluoromethoxy) ...)
Affinity DataKi:  191nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent