BDBM320845 (R)- or (S)-1-((4-tert- Butylphenyl)(cyclopropyl) methyl)-6-hydroxy- 3-(2,2,2-trifluoroethyl)- 1H-pyrazolo(3,4- d]pyrimidin-4(5H)-one::US10174037, Example 250::US10174037, Example 251

SMILES CC(C)(C)c1ccc(cc1)C(C1CC1)n1nc(CC(F)(F)F)c2c1nc(O)[nH]c2=O

InChI Key InChIKey=ZCCYAIYSNQDXGA-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 320845   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320845((R)- or (S)-1-((4-tert- Butylphenyl)(cyclopropyl) ...)
Affinity DataKi:  26nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320845((R)- or (S)-1-((4-tert- Butylphenyl)(cyclopropyl) ...)
Affinity DataKi:  27nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320845((R)- or (S)-1-((4-tert- Butylphenyl)(cyclopropyl) ...)
Affinity DataKi:  363nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent