BDBM320851 (R)- or (S)-6-Hydroxy- 3-(2,2,2-trifluoroethyl)- 1-{1-[4- (trifluoromethyl)phenyl] ethyl}-1,5-dihydro- 4H-pyrazolo[3,4- d]pyrimidin-4-one::US10174037, Example 256::US10174037, Example 257

SMILES CC(c1ccc(cc1)C(F)(F)F)n1nc(CC(F)(F)F)c2c1nc(O)[nH]c2=O

InChI Key InChIKey=OQMRFLKHFNZIRH-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 320851   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320851(US10174037, Example 257 | (R)- or (S)-6-Hydroxy- 3...)
Affinity DataKi:  0.680nMAssay Description:Performed by Lab A. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320851(US10174037, Example 257 | (R)- or (S)-6-Hydroxy- 3...)
Affinity DataKi:  0.960nMAssay Description:Performed by Lab A. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320851(US10174037, Example 257 | (R)- or (S)-6-Hydroxy- 3...)
Affinity DataKi:  1.5nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320851(US10174037, Example 257 | (R)- or (S)-6-Hydroxy- 3...)
Affinity DataKi:  2nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320851(US10174037, Example 257 | (R)- or (S)-6-Hydroxy- 3...)
Affinity DataKi:  126nMAssay Description:Performed by Lab A. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320851(US10174037, Example 257 | (R)- or (S)-6-Hydroxy- 3...)
Affinity DataKi:  166nMAssay Description:Performed by Lab A. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent