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BDBM322314 (S)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2]octan]-3'-yl)pyrazolo[1,5-b]pyridazine-3-carboxamide::US10183938, Compound (S)-80

SMILES: O=C(N[C@H]1C2CCN(CC2)C11CC1)c1cnn2ncccc12

InChI Key: InChIKey=KETCQCXSGLPUOT-AWEZNQCLSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 322314   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM322314
PNG
((S)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2...)
Show SMILES O=C(N[C@H]1C2CCN(CC2)C11CC1)c1cnn2ncccc12
Show InChI InChI=1S/C16H19N5O/c22-15(12-10-18-21-13(12)2-1-7-17-21)19-14-11-3-8-20(9-4-11)16(14)5-6-16/h1-2,7,10-11,14H,3-6,8-9H2,(H,19,22)/t14-/m0/s1
PDB

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PC cid
PC sid
UniChem
US Patent
>3.00E+4n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)


BindingDB Entry DOI: 10.7270/Q2VD71JR
More data for this
Ligand-Target Pair