BDBM322314 (S)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2]octan]-3'-yl)pyrazolo[1,5-b]pyridazine-3-carboxamide::US10183938, Compound (S)-80

SMILES: O=C(N[C@H]1C2CCN(CC2)C11CC1)c1cnn2ncccc12

InChI Key: InChIKey=KETCQCXSGLPUOT-AWEZNQCLSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 322314   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor protein alpha-7 subunit (Homo sapiens (Human))	BDBM322314 ((S)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2...) Show SMILES O=C(N[C@H]1C2CCN(CC2)C11CC1)c1cnn2ncccc12 Show InChI InChI=1S/C16H19N5O/c22-15(12-10-18-21-13(12)2-1-7-17-21)19-14-11-3-8-20(9-4-11)16(14)5-6-16/h1-2,7,10-11,14H,3-6,8-9H2,(H,19,22)/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	US Patent	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axovant Sciences GmbH US Patent					Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...				US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR
					More data for this Ligand-Target Pair