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BDBM322315 (R)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2]octan]-3'-yl)thieno[2,3-b]pyridine-2-carboxamide::US10183938, Compound (R)-81

SMILES: O=C(N[C@@H]1C2CCN(CC2)C11CC1)c1cc2cccnc2s1

InChI Key: InChIKey=QGHXMYPQSBYWFY-CQSZACIVSA-N

Data: 1 KI

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 322315   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM322315
PNG
((R)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2...)
Show SMILES O=C(N[C@@H]1C2CCN(CC2)C11CC1)c1cc2cccnc2s1
Show InChI InChI=1S/C17H19N3OS/c21-15(13-10-12-2-1-7-18-16(12)22-13)19-14-11-3-8-20(9-4-11)17(14)5-6-17/h1-2,7,10-11,14H,3-6,8-9H2,(H,19,21)/t14-/m1/s1
PDB

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PC cid
PC sid
UniChem
US Patent
1.50E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)


BindingDB Entry DOI: 10.7270/Q2VD71JR
More data for this
Ligand-Target Pair