BDBM322869 2-(azepan-1-yl)-4-((4-(2-(4-(2- hydroxyethyl)piperazin-1-yl)ethoxy) phenyl)amino)pyrimido[4,5-d]pyridazin- 5(6H)-one::US10183944, Example 239::US10647720, Ex. # 239

SMILES NC(=O)c1c(Nc2ccc(OCCN3CCN(CCO)CC3)cc2)nc(nc1C=N)N1CCCCCC1

InChI Key InChIKey=PLRVOIGCBGTLTD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 322869   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Asana Biosciences

US Patent
LigandPNGBDBM322869(2-(azepan-1-yl)-4-((4-(2-(4-(2- hydroxyethyl)piper...)
Affinity DataIC50: <100nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Asan Biosciences

US Patent
LigandPNGBDBM322869(2-(azepan-1-yl)-4-((4-(2-(4-(2- hydroxyethyl)piper...)
Affinity DataIC50:  30nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Asana Biosciences

US Patent
LigandPNGBDBM322869(2-(azepan-1-yl)-4-((4-(2-(4-(2- hydroxyethyl)piper...)
Affinity DataIC50:  75nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Asan Biosciences

US Patent
LigandPNGBDBM322869(2-(azepan-1-yl)-4-((4-(2-(4-(2- hydroxyethyl)piper...)
Affinity DataIC50: <50nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent