BDBM15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525

SMILES: c1cc(c(c(c1)Cl)C2=C3C=CC(=NN3C=NC2=O)Sc4ccc(cc4F)F)Cl

InChI Key: InChIKey=VEPKQEUBKLEPRA-UHFFFAOYSA-N

Data: 2 KI  44 IC50  802 Kd

PDB links: 3 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 854 hits for monomerid = 15244   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Mouse)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.0	30
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Mitogen-activated protein kinase 14 [G110A] (Mouse)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34	n/a	n/a	n/a	n/a	7.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 [G110D] (Mouse)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	120	n/a	n/a	n/a	n/a	7.0	30
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Platelet-derived growth factor receptor beta (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	8.40E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fgr (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Lck (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.20E+6	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL2 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Yes (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL2 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Mouse)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a
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Ephrin type-A receptor 4 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	980	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Yes (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase FRK (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a
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Ephrin type-A receptor 5 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL2 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11 (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fgr (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM15244 (cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair