BDBM5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631

SMILES: COc1cc2c(cc1OCCCN3CCOCC3)c(ncn2)Nc4ccc(c(c4)Cl)F

InChI Key: InChIKey=XGALLCVXEZPNRQ-UHFFFAOYSA-N

Data: 7 KI  279 IC50  840 Kd  3 EC50

PDB links: 8 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1165 hits for monomerid = 5447   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	240	n/a	n/a	n/a	n/a	7.5	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M] (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	318	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [L858R] (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.458	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	412	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	179	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<0.508	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	53.5	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [696-1022,G719S] (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	124	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [696-1022,L858R] (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.60	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	35.3	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [696-1022,T790M] (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.60	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [696-1022,L858R] (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.40	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [696-1022,T790M,L858R] (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	10.9	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [G719C] (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 7 (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	590	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase FRK (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
STE20-like serine/threonine-protein kinase (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Blk (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Citron Rho-interacting kinase (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Death-associated protein kinase 3 (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [1-999,L858R] (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	940	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 8 (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-G-associated kinase (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Myosin light chain kinase 2, skeletal/cardiac muscle (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.980	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5447 (ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair