BDBM32371 adenosine-derived inhibitor (Grp78), 3::adenosine-derived inhibitor, 5
SMILES CNc1nc2c(N)ncnc2n1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
InChI Key InChIKey=ISWTXTWJONWIEN-KQYNXXCUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 32371
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Leiden/Amsterdam Center For Drug Research
Curated by ChEMBL
Leiden/Amsterdam Center For Drug Research
Curated by ChEMBL
Affinity DataKi: 2.42E+3nMAssay Description:Displacement of [3H]DPCPX (without GTP) from Adenosine A1 receptor of rat cortical membraneMore data for this Ligand-Target Pair
Affinity DataKi: 8.30E+3nM ΔG°: -6.93kcal/molepH: 7.4 T: 2°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Leiden/Amsterdam Center For Drug Research
Curated by ChEMBL
Leiden/Amsterdam Center For Drug Research
Curated by ChEMBL
Affinity DataKi: 1.86E+4nMAssay Description:Displacement of [3H]DPCPX (with GTP) from Adenosine A1 receptor of rat cortical membraneMore data for this Ligand-Target Pair
Affinity DataKd: 7.46E+3nM Kon: >1M-1s-1pH: 7.4 T: 2°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
TargetHeat shock cognate 71 kDa protein(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataKd: 1.70E+4nMAssay Description:Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysisMore data for this Ligand-Target Pair
TargetHeat shock cognate 71 kDa protein(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataKd: 1.70E+4nMAssay Description:Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMpH: 7.4 T: 2°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair