BDBM32573 CHEMBL427896::arylsulfonylpiperazine, 45

SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)[N+]([O-])=O

InChI Key InChIKey=SOFGQQQVQZQJFS-MRXNPFEDSA-N

Data  4 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 32573   

LigandPNGBDBM32573(CHEMBL427896 | arylsulfonylpiperazine, 45)
Affinity DataIC50:  3nM EC50:  57nMAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM32573(CHEMBL427896 | arylsulfonylpiperazine, 45)
Affinity DataIC50:  3nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM32573(CHEMBL427896 | arylsulfonylpiperazine, 45)
Affinity DataIC50:  57nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in absence of NADPHMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Amgen

LigandPNGBDBM32573(CHEMBL427896 | arylsulfonylpiperazine, 45)
Affinity DataIC50:  53nMAssay Description:Enzyme assays were performed using purified recombinant mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed