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BDBM327570 US9663469, 109

SMILES: OCc1ncccc1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F

InChI Key: InChIKey=JQISLIRLFHEPBX-SFHVURJKSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 327570   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM327570
PNG
(US9663469, 109)
Show SMILES OCc1ncccc1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H22F7N3O5S/c27-17-5-8-19(9-6-17)42(40,41)36-18(13-23(38)35-20-2-1-11-34-21(20)14-37)7-3-15-12-16(4-10-22(15)36)24(39,25(28,29)30)26(31,32)33/h1-2,4-6,8-12,18,37,39H,3,7,13-14H2,(H,35,38)/t18-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 48.2n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H] 25-hydroxycholesterol using a scintillation proximity assay (SPA) ...


US Patent US9663469 (2017)


BindingDB Entry DOI: 10.7270/Q2ZS2ZN3
More data for this
Ligand-Target Pair