BDBM328799 1,1,1-trifluoro-2-methylpropan- 2-yl ((2S)-2-((2-amino-3,3,3- trifluoro-2- methylpropanamido)methyl)-4- ((1-(difluoromethyl)-3-ethoxy- 1H-pyrazol-4-yl)sulfonyl)-3,4- dihydro-2H- benzo[b][1,4]oxazin-6- yl)carbamate::US9663502, 34DA

SMILES CCOc1nn(cc1S(=O)(=O)N1C[C@H](CNC(=O)C(C)(N)C(F)(F)F)Oc2ccc(NC(=O)OC(C)(C)C(F)(F)F)cc12)C(F)F

InChI Key InChIKey=SBYQEYHYEKYBFR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 328799   

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM328799(US9663502, 34DA | 1,1,1-trifluoro-2-methylpropan- ...)
Affinity DataIC50: 5.05nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent