BDBM328800 (S)-1,1,1-trifluoro-2- methylpropan-2-yl (4-((3-(2,2- difluoroethoxy)-1-ethyl-1H- pyrazol-4-yl)sulfonyl)-2-((2- hydroxy-2- methylpropanamido)methyl)- 3,4-dihydro-2H- benzo[b][1,4]oxazin-6- yl)carbamate::US9663502, 34DB

SMILES CCn1cc(c(OCC(F)F)n1)S(=O)(=O)N1C[C@H](CNC(=O)C(C)(C)O)Oc2ccc(NC(=O)OC(C)(C)C(F)(F)F)cc12

InChI Key InChIKey=YNWWVWDJUTYQKZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 328800   

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM328800(US9663502, 34DB | (S)-1,1,1-trifluoro-2- methylpro...)
Affinity DataIC50: 9.63nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent