BDBM332118 US10189854, Compound 72::[1-[5-[2-Fluoro-5-(trifluoromethyloxy)-phenyl]-pyrimidin-2-yl]-spiro[1,2-dihydro-indole-3,1'-cyclopropane]-6-yl]-piperazin-1-yl-methanone

SMILES Fc1ccc(OC(F)(F)F)cc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCNCC1

InChI Key InChIKey=JFSLMHUAECOIGS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332118   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM332118(US10189854, Compound 72 | [1-[5-[2-Fluoro-5-(trifl...)
Affinity DataIC50: <100nMAssay Description:The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent