BDBM33218 Adenine, 1::CHEMBL226345::purine, 6

SMILES Nc1ncnc2nc[nH]c12

InChI Key InChIKey=GFFGJBXGBJISGV-UHFFFAOYSA-N

Data  4 IC50

PDB links: 44 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 33218   

TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM33218(Adenine, 1 | CHEMBL226345 | purine, 6)
Affinity DataIC50: >4.00E+6nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Institute Of Biological Chemistry And The Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM33218(Adenine, 1 | CHEMBL226345 | purine, 6)
Affinity DataIC50:  1.09E+4nMAssay Description:Inhibition of human xanthine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Charles University

Curated by ChEMBL
LigandPNGBDBM33218(Adenine, 1 | CHEMBL226345 | purine, 6)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Institute Of Biological Chemistry And The Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM33218(Adenine, 1 | CHEMBL226345 | purine, 6)
Affinity DataIC50:  7.56E+4nMAssay Description:Inhibition assay of the xanthine oxidase reaction by various purine based inhibitors was measured in terms of the decrease in uric acid formation at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed