BDBM333712 1-(3-(6- thoxy-7- methoxy- quinazolin- 4- ylthio)phenyl)- 3-(5- (1,1,1- trifluoro-2- methylpropan- 2-yl) isoxazol-3-yl) urea::US9730937, Example 262

SMILES CCOc1cc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3)ncnc2cc1OC

InChI Key InChIKey=OXJAHDCPGHUYSK-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 333712   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM333712(1-(3-(6- thoxy-7- methoxy- quinazolin- 4- ylthio)p...)
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM333712(1-(3-(6- thoxy-7- methoxy- quinazolin- 4- ylthio)p...)
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM333712(1-(3-(6- thoxy-7- methoxy- quinazolin- 4- ylthio)p...)
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent