BDBM33395 2,4-diaminofuro[2,3-d]pyrimidine, 1b::Z-isomer

SMILES: C/C(=C/c1coc2c1c(nc(n2)N)N)/c3ccccc3OC

InChI Key: InChIKey=JXICVPBZQSPDOK-UHFFFAOYSA-N

Data: 8 IC50

PDB links: 1 PDB ID matches this monomer.

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 33395   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Human)	BDBM33395 (Z-isomer | 2,4-diaminofuro[2,3-d]pyrimidine, 1b) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
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Vascular endothelial growth factor receptor 2 (Human)	BDBM33395 (Z-isomer | 2,4-diaminofuro[2,3-d]pyrimidine, 1b) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.52E+5	n/a	n/a	n/a	n/a	7.4	37
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Platelet-derived growth factor receptor beta (Human)	BDBM33395 (Z-isomer | 2,4-diaminofuro[2,3-d]pyrimidine, 1b) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33395 (Z-isomer | 2,4-diaminofuro[2,3-d]pyrimidine, 1b) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Human)	BDBM33395 (Z-isomer | 2,4-diaminofuro[2,3-d]pyrimidine, 1b) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Rat)	BDBM33395 (Z-isomer | 2,4-diaminofuro[2,3-d]pyrimidine, 1b) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Mouse)	BDBM33395 (Z-isomer | 2,4-diaminofuro[2,3-d]pyrimidine, 1b) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Pneumocystis carinii)	BDBM33395 (Z-isomer | 2,4-diaminofuro[2,3-d]pyrimidine, 1b) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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