BDBM336803 (S)-2-(4-(4-chloro-2-fluoro- phenoxy)phenyl)-6-(((2- oxopyrrolidin)-3-yl)amino)-methyl)pyrimidine- 4-carboxamide::US9745287, Compound 15

SMILES NC(=O)c1cc(CNC2CCNC2=O)nc(n1)-c1ccc(Oc2ccc(Cl)cc2F)cc1

InChI Key InChIKey=RKBWCMDLEUTQPV-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336803   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336803((S)-2-(4-(4-chloro-2-fluoro- phenoxy)phenyl)-6-(((...)
Affinity DataKi:  41nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336803((S)-2-(4-(4-chloro-2-fluoro- phenoxy)phenyl)-6-(((...)
Affinity DataIC50:  65nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent