BDBM33953 dihydroxy benzoyl naphthyl hydrazone (DHBNH)

SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(O)c(O)c1

InChI Key InChIKey=TVOPERZEGKBKAY-RGVLZGJSSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 33953   

TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))
Affinity DataIC50:  500nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))
Affinity DataIC50: >2.50E+4nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,Y780C]/[600-1151,Y780C](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))
Affinity DataIC50:  650nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,Y787L]/[600-1151,Y787L](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))
Affinity DataIC50:  1.20E+3nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))
Affinity DataIC50:  500nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase H using RNA-DNA hybrid duplex after 30 mins by FRET-based microplate fluorescence assayMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,L699I,K702N,C879S]/[600-1151,L699I,K702N,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))
Affinity DataIC50:  700nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))
Affinity DataIC50:  500nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of HIV1 reverse transcriptase polymerase p51/p66 after 10 to 20 mins in presence of [3H]-TTP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1028,V705A,Y780C,C879S]/[600-1151,V705A,Y780C,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))
Affinity DataIC50:  850nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair