BDBM339716 US10202339, Compound 161
SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(ccc2C2=CCOCC2)S(=O)(=O)Nc2ccccc2)c1
InChI Key InChIKey=VCEASZQXPLSQMJ-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 339716
TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Homo sapiens (Human))
Agios Pharmaceuticals
US Patent
Agios Pharmaceuticals
US Patent
Affinity DataIC50: 550nMAssay Description:Compounds were assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds were preincubated with enzyme, then the react...More data for this Ligand-Target Pair