BDBM339758 US10202339, Compound 203
SMILES FC(F)(F)CNS(=O)(=O)c1cnc(N2CCOCC2)c(NC(=O)Nc2cccc(c2)C(F)(F)F)c1
InChI Key InChIKey=CDJYPPABEITDRW-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 339758
TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Homo sapiens (Human))
Agios Pharmaceuticals
US Patent
Agios Pharmaceuticals
US Patent
Affinity DataIC50: 550nMAssay Description:Compounds were assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds were preincubated with enzyme, then the react...More data for this Ligand-Target Pair