BDBM340548 US9765040, Compound 1

SMILES: Cn1c(nnc1C(C)(C)Oc1c(F)cc(F)cc1F)-c1ccc(F)cc1Br

InChI Key: InChIKey=DFQDMZNVZFQQDG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340548   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) (Rattus norvegicus (rat))	BDBM340548 (US9765040, Compound 1) Show SMILES Cn1c(nnc1C(C)(C)Oc1c(F)cc(F)cc1F)-c1ccc(F)cc1Br Show InChI InChI=1S/C18H14BrF4N3O/c1-18(2,27-15-13(22)7-10(21)8-14(15)23)17-25-24-16(26(17)3)11-5-4-9(20)6-12(11)19/h4-8H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc US Patent					Assay Description The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...				US Patent US9765040 (2017) BindingDB Entry DOI: 10.7270/Q22N54DQ
					More data for this Ligand-Target Pair