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BDBM340548 US9765040, Compound 1

SMILES: Cn1c(nnc1C(C)(C)Oc1c(F)cc(F)cc1F)-c1ccc(F)cc1Br

InChI Key: InChIKey=DFQDMZNVZFQQDG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340548   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Rattus norvegicus (rat))
BDBM340548
PNG
(US9765040, Compound 1)
Show SMILES Cn1c(nnc1C(C)(C)Oc1c(F)cc(F)cc1F)-c1ccc(F)cc1Br
Show InChI InChI=1S/C18H14BrF4N3O/c1-18(2,27-15-13(22)7-10(21)8-14(15)23)17-25-24-16(26(17)3)11-5-4-9(20)6-12(11)19/h4-8H,1-3H3
PDB
MMDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 35n/an/an/an/an/an/a



Astellas Pharma Inc

US Patent


Assay Description
The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...


US Patent US9765040 (2017)


BindingDB Entry DOI: 10.7270/Q22N54DQ
More data for this
Ligand-Target Pair