BDBM341117 1-{2-Ethyl-7-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]-2,3-dihydro-1,4-benzodioxin-6-yl}-N-(4-hydroxyphenyl)-N-phenyl-1H-indole-3-carboxamide::US9765056, Example 185

SMILES CCC1COc2cc(c(cc2O1)C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(C)CC1)-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12

InChI Key InChIKey=ZLNWAYWHWJSDIZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341117   

TargetApoptosis regulator Bcl-2(Human)
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US Patent
LigandPNGBDBM341117(US9765056, Example 185 | 1-{2-Ethyl-7-[(3S)-3-[(4-...)
Affinity DataIC50: 17.3nMAssay Description:Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...More data for this Ligand-Target Pair
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Date in BDB:
7/29/2019
Entry Details
US Patent