BDBM341244 (S)-4-(2-(1-((2,6-diamino-5-cyanopyrimidin-4-yl)amino)ethyl)-3-(3,5-difluorophenyl)-4-oxo-3,4-dihydroquinazolin-5-yl)butanoic acid ::US9765060, Compound 71

SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CCCC(O)=O)c2c(=O)n1-c1cc(F)cc(F)c1

InChI Key InChIKey=JWLOUTWEPRZGNU-LBPRGKRZSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341244   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM341244((S)-4-(2-(1-((2,6-diamino-5-cyanopyrimidin-4-yl)am...)
Affinity DataIC50:  2nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent