BDBM341461 2-((4-chloro-2-(dimethylamino)pyrimidin-5-yl)oxy)-1-(5-(3-fluorothiophen-2-yl)-2-methyl-7,8-dihydro-[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)ethanone::US9765092, Example 1.23.11

SMILES CN(C)c1ncc(OCC(=O)N2CCc3nc4sc(C)nn4c3C2c2sccc2F)c(Cl)n1

InChI Key InChIKey=MWAFAVCCVDQCGI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341461   

TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341461(2-((4-chloro-2-(dimethylamino)pyrimidin-5-yl)oxy)-...)
Affinity DataIC50:  6nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent