BDBM342869 1-(2-cyano-4'-fluoro-5-methoxy-3'-methyl-4-biphenylyl)-N-3-isoxazolyl-6-isoquinolinesulfonamide::US9776995, Example 85

SMILES COc1cc(-c2ccc(F)c(C)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1)C#N

InChI Key InChIKey=VOUCLBNXNQZWMX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 342869   

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM342869(1-(2-cyano-4'-fluoro-5-methoxy-3'-methyl-4-bipheny...)
Affinity DataIC50: >1.00E+4nMAssay Description:293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM342869(1-(2-cyano-4'-fluoro-5-methoxy-3'-methyl-4-bipheny...)
Affinity DataIC50:  28.8nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent