BDBM342935 1-(2-cyano-3'-fluoro-5-methoxy-4-biphenylyl)-N-4-pyrimidinyl-6-isoquinolinesulfonamide::US9776995, Example 144

SMILES COc1cc(-c2cccc(F)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)C#N

InChI Key InChIKey=KHQUZJHRFAPRBS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 342935   

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM342935(1-(2-cyano-3'-fluoro-5-methoxy-4-biphenylyl)-N-4-p...)
Affinity DataIC50: >1.00E+4nMAssay Description:293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM342935(1-(2-cyano-3'-fluoro-5-methoxy-4-biphenylyl)-N-4-p...)
Affinity DataIC50:  106nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent