BDBM342964 1-(4-(5-fluoro-2-methoxy-3-pyridinyl)-2-methoxyphenyl)-N-1,3,4-thiadiazol-2-yl-6-isoquinolinesulfonamide::US9776995, Example 30

SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)-c1cc(F)cnc1OC

InChI Key InChIKey=OEKKEIOEYGMNMD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 342964   

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM342964(1-(4-(5-fluoro-2-methoxy-3-pyridinyl)-2-methoxyphe...)
Affinity DataIC50: >3.00E+4nMAssay Description:293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM342964(1-(4-(5-fluoro-2-methoxy-3-pyridinyl)-2-methoxyphe...)
Affinity DataIC50:  80.1nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent