BDBM343058 1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-4-cyano-N-3-isoxazolyl-6-isoquinolinesulfonamide::US9776995, Example 27

SMILES COc1cc(c(Cl)cc1-c1ncc(C#N)c2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(F)c1

InChI Key InChIKey=MGKGQZBKSZKWNU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 343058   

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM343058(1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-4-cy...)
Affinity DataIC50: >1.00E+4nMAssay Description:293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM343058(1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-4-cy...)
Affinity DataIC50:  282nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent