BDBM343158 1-(2-chloro-3''-fluoro-5-methoxy-4-biphenylyl)-N-3-isoxazolyl-2-methyl-3-oxo-2,3-dihydro-6-isoquinolinesulfonamide::US9776995, Example 395::US9776995, Example 396::US9776995, Example 397

SMILES COc1cc(c(Cl)cc1-c1n(C)c(=O)cc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(F)c1

InChI Key InChIKey=DVSFZSLMPMUPKE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 343158   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM343158(1-(2-chloro-3''-fluoro-5-methoxy-4-biphenylyl)-N-3...)
Affinity DataIC50:  125nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM343158(1-(2-chloro-3''-fluoro-5-methoxy-4-biphenylyl)-N-3...)
Affinity DataIC50:  1.27E+4nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM343158(1-(2-chloro-3''-fluoro-5-methoxy-4-biphenylyl)-N-3...)
Affinity DataIC50:  36nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent