BDBM34671 1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione::1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione::1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-quinone::MLS000528498::SMR000121073::US9073941, 611::cid_460747

SMILES: Cc1nn(C)c2nc(=O)n(C)c(=O)c2n1

InChI Key: InChIKey=CPXHNWKHOFNPDO-UHFFFAOYSA-N

Data: 23 IC50  2 Kd  7 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 34671   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 22 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
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DNA-(apurinic or apyrimidinic site) endonuclease (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosyl-DNA phosphodiesterase 2 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.16E+3	n/a	n/a	n/a	n/a
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Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<40	n/a	n/a	n/a	n/a	7.0	n/a
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Dihydrolipoyl dehydrogenase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	80	n/a	n/a	n/a	n/a	7.0	n/a
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RNA-editing ligase 1, mitochondrial (Trypanosoma brucei brucei)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	411	n/a	n/a	n/a	n/a	n/a	n/a
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Mitochondrial peptide methionine sulfoxide reductase (Bovine)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	6.37E+4	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	302	n/a	n/a	n/a	n/a	n/a	n/a
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Caspase-9 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25.6	n/a	n/a	n/a	n/a	n/a	n/a
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Apoptotic protease-activating factor 1 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Apoptotic protease-activating factor 1 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37.5	n/a	n/a	n/a	n/a	n/a	n/a
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Phospholipase A2 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cysteine protease ATG4B (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.73E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Protein RecA (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein phosphatase non-receptor type 7 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein phosphatase non-receptor type 22 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Mannose-6-phosphate isomerase (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.09E+3	n/a	n/a	n/a	n/a	7.4	23
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Isoform 2 of Nuclear receptor corepressor 2 (TRAC-1) (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Photoreceptor-specific nuclear receptor (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Streptokinase A (Streptococcus pyogenes M1 GAS)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.50E+5	n/a	n/a	n/a	n/a
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Transitional endoplasmic reticulum ATPase (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Transitional endoplasmic reticulum ATPase (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK1 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a
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Sphingosine 1-phosphate receptor 2 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cell division control protein 42 homolog (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.61E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.46E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.58E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Sphingosine 1-phosphate receptor 2 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Mothers against decapentaplegic homolog 3 (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
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Heat shock protein HSP 90-beta (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	946	n/a	n/a	n/a	37
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Heat shock protein HSP 90-beta (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	365	n/a	n/a	n/a	8.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Heat shock protein HSP 90-beta (Human)	BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	492	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair