BDBM34737 2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one::2-(4-methylphenyl)-1,2-benzothiazol-3-one::2-(p-tolyl)-1,2-benzothiazol-3-one::MLS000583746::SMR000200989::acs.jmedchem.1c00409_ST.174::cid_935415

SMILES: Cc1ccc(cc1)-n1sc2ccccc2c1=O

InChI Key: InChIKey=KRXMYBAZKJBJAB-UHFFFAOYSA-N

Data: 29 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 34737   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA dC->dU-editing enzyme APOBEC-3G (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.82E+4	n/a	n/a	n/a	n/a	n/a	25
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Mannose-6-phosphate isomerase (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphomannomutase 2 (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphoethanolamine/phosphocholine phosphatase (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Caspase-3 (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	466	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphomannomutase 2 (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Mannose-6-phosphate isomerase (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Lysine-specific demethylase 5B (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Lysine-specific demethylase 5B (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Replicase polyprotein 1ab (2019-nCoV)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
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Probable global transcription activator SNF2L2 (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	9.12E+4	n/a	n/a	n/a	n/a
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Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (Plasmodium falciparum 3D7)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.91E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (Plasmodium falciparum 3D7)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.48E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glucose-6-phosphate 1-dehydrogenase (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (Plasmodium falciparum 3D7)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
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DNA dC->dU-editing enzyme APOBEC-3A (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	25
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					More data for this Ligand-Target Pair
Mannose-6-phosphate isomerase (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	7.4	23
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Glucose-6-phosphate 1-dehydrogenase (Leuconostoc mesenteroides)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphotransferase (Trypanosoma brucei brucei (strain 927/4 GUTat10.1))	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Streptokinase A (Streptococcus pyogenes M1 GAS)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.50E+5	n/a	n/a	n/a	n/a
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Neutrophil cytosol factor 1 [S99G] (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Procathepsin L (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.96E+4	n/a	n/a	n/a	n/a	n/a	n/a
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M18 aspartyl aminopeptidase (Plasmodium falciparum (isolate 3D7))	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Mannose-6-phosphate isomerase (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Eukaryotic translation initiation factor 4 gamma 1 (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.52E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphoethanolamine/phosphocholine phosphatase (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.28E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphoethanolamine/phosphocholine phosphatase (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphomannomutase 2 (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Phosphomannomutase 2 (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Mannose-6-phosphate isomerase (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Mannose-6-phosphate isomerase (Human)	BDBM34737 (2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
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