BindingDB logo
myBDB logout

BDBM348915 4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)-N-(3- fluorobenzyl)benzamide::US10206907, Compound 29

SMILES: Fc1cccc(CNC(=O)c2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1

InChI Key: InChIKey=QXPXHVGWDQFSMM-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 348915   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
JAK3 (aa 781-1124)


(Homo sapiens (Human))
BDBM348915
PNG
(4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...)
Show SMILES Fc1cccc(CNC(=O)c2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1
Show InChI InChI=1S/C24H20FN5O2/c25-19-4-1-3-15(13-19)14-26-22(31)17-9-7-16(8-10-17)20-5-2-6-21-27-24(29-30(20)21)28-23(32)18-11-12-18/h1-10,13,18H,11-12,14H2,(H,26,31)(H,28,29,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Galapagos NV

US Patent


Assay Description
Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...


US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM348915
PNG
(4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...)
Show SMILES Fc1cccc(CNC(=O)c2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1
Show InChI InChI=1S/C24H20FN5O2/c25-19-4-1-3-15(13-19)14-26-22(31)17-9-7-16(8-10-17)20-5-2-6-21-27-24(29-30(20)21)28-23(32)18-11-12-18/h1-10,13,18H,11-12,14H2,(H,26,31)(H,28,29,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Galapagos NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...


US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
JAK1 (aa 850-1154)


(Homo sapiens (Human))
BDBM348915
PNG
(4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...)
Show SMILES Fc1cccc(CNC(=O)c2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1
Show InChI InChI=1S/C24H20FN5O2/c25-19-4-1-3-15(13-19)14-26-22(31)17-9-7-16(8-10-17)20-5-2-6-21-27-24(29-30(20)21)28-23(32)18-11-12-18/h1-10,13,18H,11-12,14H2,(H,26,31)(H,28,29,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Galapagos NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair