BDBM349569 US10207991, Ex. Cpd. No. 87::US10611728, Example Compound 87::US11691947, Example 87

SMILES CC(C)COc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O

InChI Key InChIKey=NBTIJJVBAGEXFD-UHFFFAOYSA-N

Data  8 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 349569   

TargetSigma intracellular receptor 2(Homo sapiens (Human))
Cognition Therapeutics

US Patent
LigandPNGBDBM349569(US10207991, Ex. Cpd. No. 87 | US10611728, Example ...)
Affinity DataKi:  1.10nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Cognition Therapeutics

US Patent
LigandPNGBDBM349569(US10207991, Ex. Cpd. No. 87 | US10611728, Example ...)
Affinity DataKi:  1.10nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Cognition Therapeutics

US Patent
LigandPNGBDBM349569(US10207991, Ex. Cpd. No. 87 | US10611728, Example ...)
Affinity DataKi:  1.10nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Cognition Therapeutics

US Patent
LigandPNGBDBM349569(US10207991, Ex. Cpd. No. 87 | US10611728, Example ...)
Affinity DataKi:  1.10nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Cognition Therapeutics

US Patent
LigandPNGBDBM349569(US10207991, Ex. Cpd. No. 87 | US10611728, Example ...)
Affinity DataKi:  69nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Cognition Therapeutics

US Patent
LigandPNGBDBM349569(US10207991, Ex. Cpd. No. 87 | US10611728, Example ...)
Affinity DataKi:  69nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Cognition Therapeutics

US Patent
LigandPNGBDBM349569(US10207991, Ex. Cpd. No. 87 | US10611728, Example ...)
Affinity DataKi:  69nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Cognition Therapeutics

US Patent
LigandPNGBDBM349569(US10207991, Ex. Cpd. No. 87 | US10611728, Example ...)
Affinity DataKi:  69nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Cognition Therapeutics

US Patent
LigandPNGBDBM349569(US10207991, Ex. Cpd. No. 87 | US10611728, Example ...)
Affinity DataIC50:  570nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent