BDBM349632 Methyl 2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl) sulfonyl)piperidin-4-ylidene)acetate::US10208016, Compound of Example 2::US10335402, Example 2

SMILES COC(=O)C(=C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1

InChI Key InChIKey=AJJRKLYODDLARY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 349632   

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349632(Methyl 2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-p...)
Affinity DataIC50:  3.10E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349632(Methyl 2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-p...)
Affinity DataIC50:  3.10E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349632(Methyl 2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-p...)
Affinity DataIC50:  3.10E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent