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BDBM3499 6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin-1-yl)propyl]amino}-1,2-bis(propan-2-yl)pyrido[2,3-d]pyrimidine-7-guanidine::6-arylpyrido[2,3-d]pyrimidine deriv. 81::N-{6-(2,6-Dichloro-phenyl)-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrido[2,3-d]pyrimidin-7-yl}-N,N-diisopropyl-guanidine

SMILES: CC(C)NC(NC(C)C)=Nc1nc2nc(NCCCN3CCN(C)CC3)ncc2cc1-c1c(Cl)cccc1Cl

InChI Key: InChIKey=REFGSJLMEHGIDI-UHFFFAOYSA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 3499   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3499
PNG
(6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin-1-...)
Show SMILES CC(C)NC(NC(C)C)=Nc1nc2nc(NCCCN3CCN(C)CC3)ncc2cc1-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C28H39Cl2N9/c1-18(2)33-28(34-19(3)4)37-26-21(24-22(29)8-6-9-23(24)30)16-20-17-32-27(36-25(20)35-26)31-10-7-11-39-14-12-38(5)13-15-39/h6,8-9,16-19H,7,10-15H2,1-5H3,(H3,31,32,33,34,35,36,37)
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PC cid
PC sid
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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Pfizer Inc



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3499
PNG
(6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin-1-...)
Show SMILES CC(C)NC(NC(C)C)=Nc1nc2nc(NCCCN3CCN(C)CC3)ncc2cc1-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C28H39Cl2N9/c1-18(2)33-28(34-19(3)4)37-26-21(24-22(29)8-6-9-23(24)30)16-20-17-32-27(36-25(20)35-26)31-10-7-11-39-14-12-38(5)13-15-39/h6,8-9,16-19H,7,10-15H2,1-5H3,(H3,31,32,33,34,35,36,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 850n/an/an/an/an/an/a



Pfizer Inc



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3499
PNG
(6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin-1-...)
Show SMILES CC(C)NC(NC(C)C)=Nc1nc2nc(NCCCN3CCN(C)CC3)ncc2cc1-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C28H39Cl2N9/c1-18(2)33-28(34-19(3)4)37-26-21(24-22(29)8-6-9-23(24)30)16-20-17-32-27(36-25(20)35-26)31-10-7-11-39-14-12-38(5)13-15-39/h6,8-9,16-19H,7,10-15H2,1-5H3,(H3,31,32,33,34,35,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Pfizer Inc



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair