BDBM350018 6-(3-amino-6-(1- (cyclopropylmethyl)- 1H-pyrazol-4- yl)pyrazin-2-yl)-2-(3,5- dimethoxyphenyl)pyridazin- 3(2H)-one 2,2,2- trifluoroacetate salt::US10208024, Example 17

SMILES: COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2CC2)c1

InChI Key: InChIKey=YYJUTCUEPVSXDM-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 350018   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM350018 (6-(3-amino-6-(1- (cyclopropylmethyl)- 1H-pyrazol-4...) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2CC2)c1 Show InChI InChI=1S/C23H23N7O3/c1-32-17-7-16(8-18(9-17)33-2)30-21(31)6-5-19(28-30)22-23(24)25-11-20(27-22)15-10-26-29(13-15)12-14-3-4-14/h5-11,13-14H,3-4,12H2,1-2H3,(H2,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	79.2	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM350018 (6-(3-amino-6-(1- (cyclopropylmethyl)- 1H-pyrazol-4...) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2CC2)c1 Show InChI InChI=1S/C23H23N7O3/c1-32-17-7-16(8-18(9-17)33-2)30-21(31)6-5-19(28-30)22-23(24)25-11-20(27-22)15-10-26-29(13-15)12-14-3-4-14/h5-11,13-14H,3-4,12H2,1-2H3,(H2,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM350018 (6-(3-amino-6-(1- (cyclopropylmethyl)- 1H-pyrazol-4...) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2CC2)c1 Show InChI InChI=1S/C23H23N7O3/c1-32-17-7-16(8-18(9-17)33-2)30-21(31)6-5-19(28-30)22-23(24)25-11-20(27-22)15-10-26-29(13-15)12-14-3-4-14/h5-11,13-14H,3-4,12H2,1-2H3,(H2,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	10.2	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair