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BDBM350018 6-(3-amino-6-(1- (cyclopropylmethyl)- 1H-pyrazol-4- yl)pyrazin-2-yl)-2-(3,5- dimethoxyphenyl)pyridazin- 3(2H)-one 2,2,2- trifluoroacetate salt::US10208024, Example 17

SMILES: COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2CC2)c1

InChI Key: InChIKey=YYJUTCUEPVSXDM-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 350018   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM350018
PNG
(6-(3-amino-6-(1- (cyclopropylmethyl)- 1H-pyrazol-4...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2CC2)c1
Show InChI InChI=1S/C23H23N7O3/c1-32-17-7-16(8-18(9-17)33-2)30-21(31)6-5-19(28-30)22-23(24)25-11-20(27-22)15-10-26-29(13-15)12-14-3-4-14/h5-11,13-14H,3-4,12H2,1-2H3,(H2,24,25)
PDB
MMDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 79.2n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM350018
PNG
(6-(3-amino-6-(1- (cyclopropylmethyl)- 1H-pyrazol-4...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2CC2)c1
Show InChI InChI=1S/C23H23N7O3/c1-32-17-7-16(8-18(9-17)33-2)30-21(31)6-5-19(28-30)22-23(24)25-11-20(27-22)15-10-26-29(13-15)12-14-3-4-14/h5-11,13-14H,3-4,12H2,1-2H3,(H2,24,25)
PDB
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PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350018
PNG
(6-(3-amino-6-(1- (cyclopropylmethyl)- 1H-pyrazol-4...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2CC2)c1
Show InChI InChI=1S/C23H23N7O3/c1-32-17-7-16(8-18(9-17)33-2)30-21(31)6-5-19(28-30)22-23(24)25-11-20(27-22)15-10-26-29(13-15)12-14-3-4-14/h5-11,13-14H,3-4,12H2,1-2H3,(H2,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.2n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair