BindingDB PrimarySearch

BDBM350085 3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-amine ::BDBM50226746::US10208027, Compound II-1::US10208027, Compound II-2::US10208027, Compound II-3::US10208027, Compound II-4::US10479784, Compound IIA-7::US10822331, Cmpd II-4::US10961232, Compound IIA-7::US11787781, Compound A

SMILES: CNCc1ccc(cc1)-c1cc(on1)-c1nc(cnc1N)-c1ccc(cc1)S(=O)(=O)C(C)C

InChI Key: InChIKey=JZCWLJDSIRUGIN-UHFFFAOYSA-N

Data: 30 KI 10 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 40 hits for monomerid = 350085
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-1-antitrypsin-related protein (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
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Serine-protein kinase ATM (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	0.148	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	0.148	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	0.165	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 3 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 9 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Mer (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 alpha (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine-protein kinase ATM (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	44	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	59	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK2 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase SYK (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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DNA-dependent protein kinase catalytic subunit (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 2 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 12 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 9 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 1 (Human)	BDBM350085 (US10208027, Compound II-1 \| US10208027, Compound I...) Show SMILES Show InChI	GoogleScholar	UniChem	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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