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BDBM352126 4-((3S,5R)-3-amino-5-methylpiperidin-1-yl)-N-((6-(2,6-difluoro-4-(((R)-3-fluoropyrrolidin-1-yl)methyl)phenyl)-5-fluoropyridin-2-yl)methyl)pyridin-3-amine::US9802918, Example 55

SMILES: C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CN2CC[C@@H](F)C2)cc1F

InChI Key: InChIKey=WSQFALZITSSASS-RLLQIKCJSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352126   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352126
PNG
(4-((3S,5R)-3-amino-5-methylpiperidin-1-yl)-N-((6-(...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CN2CC[C@@H](F)C2)cc1F
Show InChI InChI=1S/C28H32F4N6/c1-17-8-20(33)16-38(13-17)26-4-6-34-12-25(26)35-11-21-2-3-22(30)28(36-21)27-23(31)9-18(10-24(27)32)14-37-7-5-19(29)15-37/h2-4,6,9-10,12,17,19-20,35H,5,7-8,11,13-16,33H2,1H3/t17-,19-,20+/m1/s1
PDB
MMDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352126
PNG
(4-((3S,5R)-3-amino-5-methylpiperidin-1-yl)-N-((6-(...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CN2CC[C@@H](F)C2)cc1F
Show InChI InChI=1S/C28H32F4N6/c1-17-8-20(33)16-38(13-17)26-4-6-34-12-25(26)35-11-21-2-3-22(30)28(36-21)27-23(31)9-18(10-24(27)32)14-37-7-5-19(29)15-37/h2-4,6,9-10,12,17,19-20,35H,5,7-8,11,13-16,33H2,1H3/t17-,19-,20+/m1/s1
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352126
PNG
(4-((3S,5R)-3-amino-5-methylpiperidin-1-yl)-N-((6-(...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CN2CC[C@@H](F)C2)cc1F
Show InChI InChI=1S/C28H32F4N6/c1-17-8-20(33)16-38(13-17)26-4-6-34-12-25(26)35-11-21-2-3-22(30)28(36-21)27-23(31)9-18(10-24(27)32)14-37-7-5-19(29)15-37/h2-4,6,9-10,12,17,19-20,35H,5,7-8,11,13-16,33H2,1H3/t17-,19-,20+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair