BDBM352598 (S)-2-(6-((tert-butoxycarbonyl)amino)-4- ((3-chloro-4-fluorophenyl)sulfonyl)-3,4- dihydro-2H-benzo[b][1,4]oxazin-2- yl)acetic acid::US10745364, Example 32C::US9809561, 32C

SMILES CC(C)(C)OC(=O)Nc1ccc2O[C@@H](CC(O)=O)CN(c2c1)S(=O)(=O)c1ccc(F)c(Cl)c1

InChI Key InChIKey=GSRASZJHXDQHTL-ZDUSSCGKSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352598   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352598((S)-2-(6-((tert-butoxycarbonyl)amino)-4- ((3-chlor...)
Affinity DataIC50:  51.8nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352598((S)-2-(6-((tert-butoxycarbonyl)amino)-4- ((3-chlor...)
Affinity DataIC50:  51.8nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352598((S)-2-(6-((tert-butoxycarbonyl)amino)-4- ((3-chlor...)
Affinity DataIC50:  51.8nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent