BDBM355505 N-{1-[2-fluoro-4- (trifluoromethyl)phenyl]-1- methylethyl}-2-methyl-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US9815796, Example 596

SMILES Cc1nc(cc(=O)[nH]1)C(=O)NC(C)(C)c1ccc(cc1F)C(F)(F)F

InChI Key InChIKey=GDLFXKLSGTTXBY-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355505   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355505(US9815796, Example 596 | N-{1-[2-fluoro-4- (triflu...)
Affinity DataKi:  22nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355505(US9815796, Example 596 | N-{1-[2-fluoro-4- (triflu...)
Affinity DataKi:  30nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent