BDBM35585 pyrazolo pyrimidine, 18

SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC)c2n1

InChI Key InChIKey=HRGYHCLHXQJDHS-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 35585   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35585(pyrazolo pyrimidine, 18)
Affinity DataIC50:  0.460nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM35585(pyrazolo pyrimidine, 18)
Affinity DataIC50:  100nMT: 2°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35585(pyrazolo pyrimidine, 18)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of Flag-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM35585(pyrazolo pyrimidine, 18)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of ATR by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35585(pyrazolo pyrimidine, 18)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM35585(pyrazolo pyrimidine, 18)
Affinity DataIC50:  100nMAssay Description:Inhibition of PI3Kalpha by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM35585(pyrazolo pyrimidine, 18)
Affinity DataIC50:  148nMAssay Description:Inhibition of PI3Kgamma by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM35585(pyrazolo pyrimidine, 18)
Affinity DataIC50:  100nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed