BDBM356249 US10604535, Example 13::US11072607, Example #10::US9815850, Compound 13::US9896458, No. 13

SMILES CN1c2ccccc2OC[C@H](NC(=O)c2cc3[C@H](CCn3n2)c2ccccc2)C1=O

InChI Key InChIKey=ZXSMJBMMAAHHKL-AEFFLSMTSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 356249   

TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM356249(US10604535, Example 13 | US11072607, Example #10 |...)
Affinity DataKi:  9nMAssay Description:The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is monitored using...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM356249(US10604535, Example 13 | US11072607, Example #10 |...)
Affinity DataKi:  28nMAssay Description:The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is monitored using...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM356249(US10604535, Example 13 | US11072607, Example #10 |...)
Affinity DataIC50:  500nMAssay Description:Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM356249(US10604535, Example 13 | US11072607, Example #10 |...)
Affinity DataIC50:  500nMAssay Description:Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM356249(US10604535, Example 13 | US11072607, Example #10 |...)
Affinity DataIC50: <1.00E+3nMAssay Description:Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent