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BDBM356271 US10604535, Example 169::US9815850, Compound 169::US9815850, Compound 42::US9896458, No. 169

SMILES: CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O

InChI Key:

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 356271   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356271
PNG
(US10604535, Example 169 | US9815850, Compound 169 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
PDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356271
PNG
(US10604535, Example 169 | US9815850, Compound 169 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356271
PNG
(US10604535, Example 169 | US9815850, Compound 169 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356271
PNG
(US10604535, Example 169 | US9815850, Compound 169 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356271
PNG
(US10604535, Example 169 | US9815850, Compound 169 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356271
PNG
(US10604535, Example 169 | US9815850, Compound 169 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair