BDBM35723 CHEMBL344159::N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide::TOLVAPTAN::benzazepine derivative, 32

SMILES: Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3cc(Cl)ccc23)c(C)c1

InChI Key: InChIKey=GYHCTFXIZSNGJT-UHFFFAOYSA-N

Data: 15 KI  9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 35723   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-binding cassette sub-family C member 3 (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Vasopressin V2 receptor (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Vasopressin V1a receptor (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.00700	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 4 (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.99E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	4
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ATP-binding cassette sub-family C member 2 (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Vasopressin V1a receptor (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	580	n/a	n/a	n/a	n/a	7.4	4
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		0.430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		0.430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		0.830	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Corticotropin-releasing factor receptor 1 (Rat)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Mouse)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		1.26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Rat)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		1.33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rat)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vasopressin V1a receptor (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		12.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vasopressin V1a receptor (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vasopressin V1a receptor (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		296	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vasopressin V1a receptor (Rat)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		325	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vasopressin V1b receptor (Human)	BDBM35723 (N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair