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BDBM357432 US10214519, Example 162

SMILES: Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)N1CCOCC1)-c1nnco1

InChI Key: InChIKey=YLXVCEZXJBGNMA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 357432   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357432
PNG
(US10214519, Example 162)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)N1CCOCC1)-c1nnco1
Show InChI InChI=1S/C23H19ClN6O2/c1-14-27-22-17(23-28-26-13-32-23)11-15(29-7-9-31-10-8-29)12-20(22)30(14)19-5-6-25-21-16(19)3-2-4-18(21)24/h2-6,11-13H,7-10H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 77n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F5Q
More data for this
Ligand-Target Pair