BDBM357950 N-(3-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H- pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)benzyl) methanesulfonamide::US10214537, Example 18

SMILES CS(=O)(=O)NCc1cccc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12

InChI Key InChIKey=KUMSKEWHKYFECJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 357950   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM357950(N-(3-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H- ...)
Affinity DataIC50:  10nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM357950(N-(3-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H- ...)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM357950(N-(3-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H- ...)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed