BDBM358014 3-(4-amino-5-(1-(tetrahydro-2H-pyran- 4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-fluoro-N-(3- hydroxy-2,2-dimethylpropyl)-N- methylbenzamide::US10214537, Example 83

SMILES CN(CC(C)(C)CO)C(=O)c1cc(F)cc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12

InChI Key InChIKey=KXSRMVBZHNRJLW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358014   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM358014(3-(4-amino-5-(1-(tetrahydro-2H-pyran- 4-yl)-1H-pyr...)
Affinity DataIC50:  6nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent